III. Community Profiles

Community Profiles are defined as "Schema Compositions" that constrain a core class (rather than subclass it). Each community groups a set of Statement and Evidence Line profiles; the domain-specificity of each is set by the Proposition profile it encapsulates.

constraint_over

Community Profiles

ACMG 2015

Statement

Variant Pathogenicity
Statement

Variant Pathogenicity Proposition

Evidence Line

Variant Pathogenicity
Evidence Line

Variant Pathogenicity Proposition

CCV 2022

Statement

Variant Oncogenicity
Statement

Variant Oncogenicity Proposition

Evidence Line

Variant Oncogenicity
Evidence Line

Variant Oncogenicity Proposition

AAC 2017

Statement

Variant Clinical
Significance Statement

Variant Clinical Significance Proposition

Evidence Lines

AMP/ASCO/CAP
Evidence Line

Diagnostic / Prognostic / Therapeutic Response Proposition

Diagnostic
Evidence Line

Variant Diagnostic Proposition

Prognostic
Evidence Line

Variant Prognostic Proposition

Therapeutic
Evidence Line

Variant Therapeutic Response Proposition

constraint_over (schema composition) community grouping (not a schema class)