Statement Data Structure

A class-level view of the Statement-based structure in VA-Spec data. Italicized text in each class exemplifies the kind of information it may capture — here a Variant Pathogenicity Statement supported by population allele-frequency evidence.

Statement

Proposition

'HRAS:c.173C>T is causal for Costello Syndrome'

is supported with high confidence

Evidence Line

e.g. pop-freq data provides a moderate argument supporting pathogenicity

InformationEntity

«Study Result»

e.g. pop-freq study data: alleleCount=341, alleleFreq=0.002, …

Method

(e.g. interpretation guidelines, experimental protocols)

Document

(e.g. publications, database records)

Contribution

(who, when, and how an agent contributed to an artifact)

Agent

(e.g. persons, organizations, software)

central artifact (Information Entity) provenance class arrow points from a class to the object it references; label shows the attribute & cardinality