JSON Schema Catalog

Formal JSON schema files for Base and Community Profiles are stored across different directories in the VA-Spec repository.

To facilitate developer access to these key resources, we provide this central catalog of links for all VA Profile json schema files.

Study Result Base Profiles:

• Cohort Allele Frequency Study Result Json Schema

• Experimental Variant Functional Impact Study Result Json Schema

• Tumor Variant Frequency Study Result Json Schema

Proposition Base Profiles:

• Pathogenicity Proposition Json Schema

• Oncogenicity Proposition Json Schema

• Therapeutic Response Proposition Json Schema

• Diagnostic Proposition Json Schema

• Prognostic Proposition Json Schema

• Experimental Variant Functional Impact Proposition Json Schema

Statement Community Profiles:

• Pathogenicity Statement Json Schema (ACMG-2015)

• Oncogenicity Study Statement Json Schema (CCV-2022)

• Variant Clinical Significance Statement Json Schema (AAC-2017)

Evidence Line Community Profiles:

These profiles constrain the core Evidence Line class.

• Amp Asco Cap Evidence Line Json Schema (AAC-2017) – the shared base composed by the three AAC-2017 evidence-line profiles below

• Pathogenicity Evidence Line Json Schema (ACMG-2015)

• Oncogenicity Evidence Line Json Schema (CCV-2022)

• Diagnostic Evidence Line Json Schema (AAC-2017)

• Prognostic Evidence Line Json Schema (AAC-2017)

• Therapeutic Evidence Line Json Schema (AAC-2017)

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JSON schema for concrete VA Core classes that can also be used to create and validate data are housed in the directory here: Core Class Json Schema Files.

This includes schema for the Statement and EvidenceLine classes that are the basis for all constraint-based Community Profiles - both those describing Statements and those describing Evidence Lines - as well as schema for Method, Document, Data Set, Contribution, and Agent classes that support provenance representations within all Profiles.